Saturday, June 19, 2010

How to cure DNA

DNA repair refers to a set of processes by which a cell identifies and corrects damage to DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as light and UV radiation can damage DNA, causing up to 1 million individual molecular lesions per cell day. Most of these lesions cause structural damage to the DNA molecule and may modify or eliminate the ability of the cell to transcribe the gene encoding the DNA concerned. Other lesions induce potentially harmful mutations in the genome of the cell, affecting the survival of its daughter cells after undergoing mitosis. Thus, the process of DNA repair is constantly active, it responds to damage the structure of DNA. When the normal repair process does not, and when there is no apoptosis, DNA irreparable damage may occur including DNA crosslinks and DNA double-strand.


Number of DNA repair depends on many factors, including cell type, age of the cell and extracellular environment. Cell, which has accumulated a large amount of DNA damage, or no longer effectively repairs damage to DNA, can come in three different states: an irreversible state of dormancy, ie the aging of the two cell suicide, which is also known as apoptosis or programmed cell death 3 unregulated cell division, which can lead to the formation of a tumor is the ability of a tumor cell DNA repair is essential for the integrity of its genome, and then normal operation and the body. Many of the genes, which were originally shown to influence lifespan have been shown to be involved in the repair of DNA damage and protection. Failure to correct molecular lesions in cells that form gametes can be included mutations in the genome of the offspring and thus influence the evolution.

No comments:

Post a Comment